This white paper explores a cutting-edge 3D printing application of Evonik’s RESOMER® biomaterials in the reconstruction of a critical-size large segmental bone defect of a Ukraine war victim. A patient-specific, 3D-printed, resorbable scaffold was meticulously designed by BellaSeno and successfully applied clinically, demonstrating the transformative potential of next-generation biomaterials in enhancing patient outcomes in complex reconstructive surgeries.