Boosting cell culture performance with cQrex® peptides in biopharma applications

Over the past decade, optimization of cell culture media has become a key strategy for obtaining high yields and productivity while ensuring product quality in the manufacture of biopharmaceuticals. However, some critical amino acids commonly included in media formulations have properties that limit performance in mammalian cell culture. Further bioprocess intensification is limited by undesired media chemistry that negatively impacts cell metabolism and the final product quality.

As a pioneer for high-quality cell culture solutions, Evonik has designed the cQrex® peptides to overcome two well-known challenges: stability and solubility enhancement of media ingredients. These chemically defined, non-animal-derived peptides can be used to formulate more concentrated media, simplify the cell culture bioprocess and achieve higher productivity at lower production costs.

Overview

In this whitepaper, Evonik demonstrates the ability of glutamine, tyrosine and cystine peptides to replace the corresponding free amino acids in cell culture media. Based on recent screenings with different MSCs (mesenchymal stem cells) and CHO (Chinese hamster ovary) cell lines, Evonik is investigating the influence of cQrex® peptides on media chemistry and highlights their positive impact on bioprocesses and overall cell culture performance.

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